The Chemical Synthesis Department in a pharmaceutical company plays a crucial role in discovering, developing, and producing drug molecules.
Key Responsibilities:
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Drug Discovery Support:
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Design and synthesize potential drug candidates.
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Optimize molecular structures for better efficacy, safety, and bioavailability.
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Process Development:
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Develop scalable and cost-effective synthetic routes for APIs.
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Optimize reaction conditions (temperature, pressure, solvents, catalysts).
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Scale-Up and Pilot Production:
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Translate lab-scale synthesis to pilot plant or industrial scale.
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Ensure consistency, purity, and yield at larger volumes.
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Collaboration with Other Departments:
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Work with analytical chemistry to verify product identity and purity.
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Coordinate with formulation, quality assurance, and regulatory teams.
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Documentation & Compliance:
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Maintain detailed records for regulatory submissions (e.g., FDA).
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Follow Good Manufacturing Practices (GMP) and safety protocols.
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Technologies and Techniques Used:
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Organic synthesis and medicinal chemistry
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High-throughput screening
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Flow chemistry and automation
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Catalysis and green chemistry methods
