The Production Department for Oral Solid Dosage (OSD) in the pharmaceutical industry is responsible for manufacturing solid dosage forms such as tablets, capsules, and powders. This department plays a crucial role in ensuring that the products meet strict regulatory and quality standards for efficacy, safety, and consistency. Here's an overview of its primary functions:
Key Functions of the OSD Production Department:
1. Raw Material Handling
- Receipt, inspection, and storage of active pharmaceutical ingredients (APIs) and excipients.
- Ensuring materials comply with Good Manufacturing Practices (GMP) and are properly documented.
2. Dispensing
- Accurate measurement and weighing of raw materials according to the batch manufacturing record (BMR).
- Cross-verification to prevent contamination or mix-ups.
3. Granulation
- Wet Granulation: Blending raw materials with a granulating fluid to form granules.
- Dry Granulation: Compressing and milling materials to achieve granules without a liquid binder.
4. Blending
- Mixing APIs with excipients to ensure uniform distribution of active ingredients.
5. Compression
- Compressing blended powders or granules into tablets using tablet presses.
- Ensuring uniformity in weight, thickness, and hardness of tablets.
6. Encapsulation
- Filling powders or granules into capsules (hard gelatin or soft gelatin) using encapsulating machines.
- Ensuring proper fill weight and sealing.
7. Coating
- Applying coatings to tablets for taste masking, protection, controlled release, or aesthetic purposes.
- Common types: film coating, sugar coating, and enteric coating.
8. Drying
- Reducing moisture content in granules using techniques like fluid bed drying or tray drying to meet required specifications.
9. Packaging
- Blister packaging, strip packaging, or bottle filling to ensure product integrity.
- Labeling and ensuring compliance with regulatory requirements.
10. Cleaning and Maintenance
- Cleaning equipment between batches to prevent cross-contamination.
- Routine maintenance and calibration of machinery to ensure consistent performance.
Regulatory Compliance
The production department ensures adherence to:
- Good Manufacturing Practices (GMP)
- Standard Operating Procedures (SOPs)
- Quality Management Systems (QMS)
- Regulatory bodies like FDA, EMA, and WHO guidelines.
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Common Challenges
- Maintaining batch-to-batch consistency.
- Managing deviations and process validation.
- Preventing contamination or mix-ups.
- Ensuring high production efficiency and cost control.
Position:Production OSD Trainee
Department:Production (Oral Solid Dosage)
Location:Boisar
Experience:Fresher
Qualification:B. Pharma (Preferably pass out of 2024/2023)
Key Responsibilities:
• Handle production-related activities.
• Oversee and manage the entire manufacturing process.
• Conduct in-process checks at various stages.
• Maintain online documentation of production activities.
Apply now ashwini.thakur@ashishlifescience.com or Whataspp at 8657907267 and kick-start your career in pharmaceutical production!
